Luminescent technology at your fingertips
The CALCIVIS® Imaging System allows you to detect and assess demineralization associated with carious lesions.
Intuitive and Easy Imaging
Provides demineralization maps of the tooth surfaces in real time.
A rapid, fully automated imaging process
A visible image is taken of the tooth surface with the LED light on. Immediately afterwards the LED switches off and the CALCIVIS® photoprotein is sprayed onto the surface. A second image is then taken of the bioluminescence from the light generated by the interaction between the CALCIVIS® photoprotein and free calcium ions.
Treatment and monitoring when luminescent activity is detected
Repair enamel structures and protect against further damage:
- Active caries enamel lesion – requires arrest and remineralization (cleaning and ‘painting’) and management of the ongoing plaque challenge
- Specific treatment actions will depend on your personal approach and the individual patient’s situation. However, the International Caries Classification and Management System (ICCMS) guidelines provide useful guidance.
A system that is safe and effective
The CALCIVIS® Imaging System has undergone extensive pre-clinical and clinical evaluation.1-6 There have been three main clinical studies of the CALCIVIS® Imaging System.
These studies have demonstrated that the CALCIVIS® Imaging System can:
- Differentiate active caries lesions, as determined by comparison with current best clinical practice, from sound tooth surfaces7
- Be used safely and is pain free for adult and pediatric patients aged 6 years and above8,9
A Focus On Prevention
- A Rapid Non-invasive Diagnostic
- Early detection of sub-clinical demineralization activity associated with carious lesions
- Real time visual results enable increased patient engagement and motivation
- A supportive aid in determination of treatment planning and monitoring
Early diagnosis enables you and your patient to make a decision on the best treatment option for their dental caries.
Next-level care that’s accurate, rapid and pain-free
The CALCIVIS® Imaging System is a significant advance in preventive dentistry that allows your patients to visualize early signs of active decay during routine exams.
This novel technology gives you the opportunity to arrest or reverse demineralization before tissue destruction has occurred.
Integrated Personalized Treatment Planning
Overview of the International Caries Classification and Management System (ICCMS) 4D caries management system; the CALCIVIS® Imaging System provides information for the lesion activity assessment.
Detect
Visual Detection Aids Lesion Activity Assessment
Determine
Caries Risk Assessment
Dentition/Lesion Activity Assessment
Decide
Lesion Prognosis/Diagnosis
Patient Assessment/Prognosis
Do
Background Level Care
Preventive/Operative Treatment Options
Recall Reassessment
- Jablonski-Momeni A, Kneib L. Assessment of caries activity using the CALCIVIS caries activity imaging system. Open Access J Sci Technol 2016;4 Article IDF 101241. Available at doi:10.11131/2016/101241 [accessed August 2017].
- Martignon S, Cortes A, Pitts NB, Ekstrand KR, Cabrera DF, Avila V, et al. Caries-activity assessment: Agreement among examiners from clinical assessments ex-vivo and assessments from bio-luminescent marker images. Poster at the 64th European Organisation for Caries Research (ORCA) Congress, July 5–8, 2017, Oslo, Norway: 100 2017.
- Subka S, Rodd H, Nugent Z, Deery C. The optimum laser fluorescence cut-off values for the detection of approximal caries in primary molars. Poster at the 64th European Organisation for Caries Research (ORCA) Congress, July 5–8, 2017, Oslo, Norway: 111.
- Gallie A, Vernon B, Alision B. Evaluation of the CALCIVIS Imaging System’s ability to assess erosive challenge to enamel over time. Poster at the 64th European Organisation for Caries Research (ORCA) Congress, July 5–8, 2017, Oslo, Norway: 35.
- Neuhaus KW, Vernon B, Kennedy A, Alison S, Lussi A. Evaluation of Chemiluminescence for detection of enamel caries lesion activity. Poster at the 64th European Organisation for Caries Research (ORCA) Congress, July 5–8, 2017, Oslo, Norway: 122.
- Vernon B, Kennedy A, Alison S. Evaluation of the CALCIVIS Imaging System for persistence of images on tooth enamel surfaces. Poster at the 64th European Organisation for Caries Research (ORCA) Congress, July 5–8, 2017, Oslo, Norway: 113.
- Pitts NB et al. Clinical validation of a novel bioluminescence imaging technology for aiding the assessment of carious lesion activity status. Clin Exp Dent Res. Oct 2021; 7(5):772-785.
- ClinicalTrials.gov. Post-approval clinical study to evaluate the CALCIVIS caries activity imaging system. NCT02098304. Available at www.clinicaltrials.gov/ct2/show/NCT02098304 (accessed August 2017).
- Ormond C, Willins M, Vernon B, Christie A, Longbottom C, Pitts NB. Clinical study – Safety and performance evaluation of the advanced prototype CALCIVIS caries activity imaging system. Poster at the 63rd European Organisation for Caries Research (ORCA) Congress, July 6–9, 2016, Athens, Greece: P105.